New Haven — Yale-New Haven Hospital will officially acquire the Hospital of Saint Raphael Tuesday, creating one of the largest hospitals in the United States with 1,519 beds.

Both hospitals will close the more than $160 million deal and hold a press conference Tuesday featuring hospital officials and New Haven Mayor John DeStefano. The deal will give Yale-New Haven another 511 beds and raise the total number of employees to 12,000.

The arrangement, the result of about 18 months of negotiations, will create a two-campus hospital in New Haven.

State Attorney General George Jepsen, who had launched an antitrust investigation into the merger, announced in June that he would not block it. Among the factors leading to his decision was St. Raphael’s “precarious financial condition” and the expected efficiencies the deal would create.

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