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Pfizer could have 50 million coronavirus vaccine doses manufactured by year’s end

  • Health
  • by Keith M. Phaneuf
  • November 9, 2020
  • View as "Clean Read" "Exit Clean Read"

Tyler Russell/Connecticut Public

Pfizer campus in Groton on July 22. The pharmaceutical giant announced that early trials of a coronavirus vaccine are 90% effective.

A limited supply of coronavirus vaccine could be available for some of Connecticut’s care providers and most vulnerable residents by early 2021 — provided several key benchmarks, including emergency federal approval, are achieved by year’s end, a top executive for Pfizer Inc. told Gov. Ned Lamont late Monday.

The Groton-based drug manufacturer announced Monday morning that early trials of the coronavirus vaccine it’s been developing have been about 90% effective.

Early results also showed the coronavirus vaccine’s effectiveness is similar to that of long-established children’s vaccines such as the inoculation for measles. It still is unclear how long patients would remain protected by the vaccine.

A plan to manufacture at least five million to 10 million doses — and possibly as many as 50 million doses — by the end of December is moving forward, said John Burkhardt, senior vice president and global head of drug safety at Pfizer.

Neither Burkhardt nor Lamont could say late Monday how many of those doses would be distributed in Connecticut.

The vaccine, which Pfizer has developed in conjunction with BioNTech, a German pharmaceutical firm, requires two doses to inoculate one patient. That means enough vaccines to protect anywhere from 2.5 million to 25 million patients could be produced by January if Pfizer meets its projections.

“It’s good news,” but “it’s going to take many months to roll out,” Lamont said during a televised news briefing at which he cautioned residents against relaxing social distancing and other safeguards. “Don’t take anything for granted.”

COVID-19 infection test rates have risen steadily in Connecticut since mid-August. After remaining around 1% for much of the summer, the weekly rate now stands at 3.8% with nearly 500 residents currently hospitalized with the virus — an increase of 94 since Friday. Another 27 people were reported dead from the coronavirus Monday, bringing the statewide total to 4,698 since the pandemic began.

A crucial next step to battle the virus, Burkhardt said, involves completing a detailed, early analysis of safety-related tests tied to the vaccine. No serious side effects or other safety concerns initially were discovered.

Pfizer hopes to take that safety data to the U.S. Food and Drug Administration by the end of November and seek emergency authorization for drug manufacture and distribution.

This process occurs very quickly, Burkhardt said, adding, “I would expect weeks rather than months.”

If granted, Pfizer then would immediately pursue federal approval for large-scale manufacture with the goal of producing about one billion doses — enough to inoculate 500 million patients — by the end of 2021, he added.

Despite the accelerated process, “no corners were cut,” and the company conducted efficacy tests while simultaneously planning for manufacturing. “We followed this true-and-true methodology,” Burkhardt said.

Meanwhile, a Lamont task force is moving forward with developing prioritization and distribution plans for a vaccine in Connecticut.

Dr. Reginald Eadie, president and CEO of Trinity Health of New England — the chain that includes St. Francis Hospital in Hartford — said that process isn’t completed, but health care workers, nursing homes and elderly residents in general would receive top priority.

Because the coronavirus vaccine must be kept extremely cold, distribution also would hinge on facilities and agencies with the resources to store the drug safely, Eadie said. That most likely would mean relying heavily on hospitals and local health districts as the chief distributors of the vaccine, he added.

Pfizer’s work involves one of four vaccine efforts that are in late stage trials in the U.S., and one of 11 globally.

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ABOUT THE AUTHOR

Keith M. Phaneuf A winner of numerous journalism awards, Keith Phaneuf has been CT Mirror’s state finances reporter since it launched in 2010. The former State Capitol bureau chief for The Journal Inquirer of Manchester, Keith has spent most of 31 years as a reporter specializing in state government finances, analyzing such topics as income tax equity, waste in government and the complex funding systems behind Connecticut’s transportation and social services networks. A former contributing writer to The New York Times, Keith is a graduate of and a former journalism instructor at the University of Connecticut.

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